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Project title

Development of Green Catalytic Methodology for Alkylation of Nucleophiles, Starting from Alcohols

Primary Funding Agency

Irish Research Council

Co-Funding Organisation(s)

n/a

Lead Organisation

University College Cork (UCC)

Lead Applicant

n/a

Project Abstract

Alkyl halides are a type of chemical that is widely used in industrial production of medicines/drugs. However, the use of alkyl halides can be problematic in some instances, because these compounds are cancer-causing (carcinogenic). Indeed, there exist reports in the chemical literature of contamination of certain drug products with alkyl halides. Problems of this type can arise when alkyl halides are used in the final steps of production of a drug. In this project, prompted by the consequent need to minimise or eliminate alkyl halide contamination of drug products, we will develop a new way of safely accessing the products that typically require use of alkyl halides to access them. To do this, we will use a �green� approach, employing only environmentally benign, non-toxic reagents and catalysts that are available from sustainable sources. The proposed approaches directly address key Green Chemistry targets identified by industrial pharmaceutical companies contributing to the American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable, and have the potential to significantly increase the efficiency of pharmaceutical production in the long-term.

Grant Approved

�87,000.00

Research Hub

n/a

Research Theme

Climate Solutions, Transition Management and Opportunities

Start Date

01/09/2022

Initial Projected Completion Date

31/08/2026