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Project Code [2006-PhD-RCA-18]
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Project title
Advanced systems for biological assessment of toxicity of industrial chemicals
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
University College Cork (UCC)
Lead Applicant
DmitriB Papkovsky
Project Abstract
A new methodology for biological testing of industrial chemicals and environmental samples has been developed which is based on the measurement of oxygen consumption of model organisms (microbial and mammalian cells and aquatic organisms) using phosphorescent oxygen-sensitive probes and detection on a fluorescent reader. Assays for neurotoxins and pesticides were developed which use coupled cholinesterase/choline oxidase system with acetylcholine and dissolved oxygen as substrates. These respirometric assays were validated with real samples. They provide good sensitivity simplicity high samples throughput and convenience; they are well suited for environmental monitoring and toxicity testing applications. A portable system for the analysis of VOC in sealed vials was also developed which uses solid state oxygen sensors and a benchtop reader.
Grant Approved
�90,000.00
Research Hub
Healthy Environment
Research Theme
Environment and Human Health
Initial Projected Completion Date
01/06/2011