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Project Code [2008-S-ET-1]
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Project title
An environmental analysis of biopharmaceutical manufacturing in recombinant E. coli, with a view to waste
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
University of Limerick (UL)
Lead Applicant
Gary Walsh
Project Abstract
In biopharmaceutical manufacturing operations fermentation processes (upstream processing) require significant nutrient inputs which, if only partially utilised, will result in the generation of significant volumes of nutrient-containing wastewaters. This leads to a reliance on end-of-pipe technologies for phosphorous (P) and nitrogen (N) removal. This project focuses on (a): the potential minimization of P and N inputs during upstream processing and (b) assessment of the various chromatographic modalities typical of biopharmaceutical downstream processing in the context of potential environmental impact. The overall project aim is to minimize the process input content of nutrients, in particular phosphorus and nitrogen, in order to achieve a reduction in the need for end-of-pipe technologies.
Grant Approved
�40,000.00
Research Hub
Natural Environment
Research Theme
Protecting our Water Resources
Initial Projected Completion Date
13/04/2010