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Project Code [2007-PhD-EH-4]

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Project title

An investigation of the disease-causing potential of environmentalisolates of Aspergillus fumigatus

Primary Funding Agency

Environmental Protection Agency

Co-Funding Organisation(s)

n/a

Lead Organisation

Maynooth University (MU)

Lead Applicant

Kevin Kavanagh

Project Abstract

The fungus Aspergillus fumigatus is major cause of disease among immunocompromised patientsand is a common contaminant of domestic dwellings in Ireland. We wish to examine the possibilitythat environmental isolates of this fungus are capable of initiating disease and that toxins secretedby this fungus have the ability to inhibit the function of neutrophils which are a major element of thehost?s immune response. We postulate that environmental isolates of this fungus are virulent andproduce toxins that may act on the immune system of susceptible patients (e.g cystic fibrosis) andmake them prone to secondary bacterial infections.

Grant Approved

�94,748.00

Research Hub

Healthy Environment

Research Theme

Environment and Human Health

Start Date

17/09/2007

Initial Projected Completion Date

17/03/2011