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Project Code [2007-PhD-EH-4]
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Project title
An investigation of the disease-causing potential of environmentalisolates of Aspergillus fumigatus
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
Maynooth University (MU)
Lead Applicant
Kevin Kavanagh
Project Abstract
The fungus Aspergillus fumigatus is major cause of disease among immunocompromised patientsand is a common contaminant of domestic dwellings in Ireland. We wish to examine the possibilitythat environmental isolates of this fungus are capable of initiating disease and that toxins secretedby this fungus have the ability to inhibit the function of neutrophils which are a major element of thehost?s immune response. We postulate that environmental isolates of this fungus are virulent andproduce toxins that may act on the immune system of susceptible patients (e.g cystic fibrosis) andmake them prone to secondary bacterial infections.
Grant Approved
�94,748.00
Research Hub
Healthy Environment
Research Theme
Environment and Human Health
Initial Projected Completion Date
17/03/2011