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Project Code [2012-WRM-PhD-6]

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Project title

Biodegradable Ionic Liquids

Primary Funding Agency

Environmental Protection Agency

Co-Funding Organisation(s)

n/a

Lead Organisation

Dublin City University (DCU)

Lead Applicant

Andrew Kellett

Project Abstract

To demonstrate that by assessing the toxicity, ecotoxicity and biodegradation of a novel class of compounds as part of the discovery or early development stage of a project, the selection of a preferred or �fit-for-purpose� chemical can be directed towards safer and greener candidates. To achieve this we are investigating a series of IL compounds containing amide group(s). Following on from previous EPA funded studies, in the Gathergood group, on the development of biodegradable and low antimicrobial toxicity ionic liquids, this project will focus on amide containing ionic liquids. This will involve the synthesis of a range of dipeptides, tripeptides and peptidomimetics. Antimicrobial, cytotoxicity and biodegradation screening of compounds will take place with collaborators in the Czech Republic and Spain as well as in DCU. The results from the biological studies will then be fed back into the further design, optimisation and subsequent iterative development of second and third generation compounds. The most common method to improve biodegradation is the introduction of an ester group, but this limits the applications of the IL. ILs containing amides will allow a broader scope. Targets will be selected based on feedback from industry and academic partners.

Grant Approved

�73,500.00

Research Hub

Green and Circular Economy

Research Theme

Waste and Resources Management

Start Date

01/01/2013

Initial Projected Completion Date

01/01/2016