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Project Code [2008-PhD-WRM-3]

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Project title

Fungi and fluorinated drugs the development of microbial models of mammalian metabolism

Primary Funding Agency

Environmental Protection Agency

Co-Funding Organisation(s)

n/a

Lead Organisation

University College Dublin (UCD)

Lead Applicant

Cormac Murphy

Project Abstract

Drug discovery necessitates the use of animals for catabolic and toxicological studies. The European Union?s REACH initiative has as one of its priorities the development of novel methods to replace the dependence on animal testing. To this end it is proposed to investigate the potential of the fungus Cunninghamella elegans and the bacterium Streptomyces giseus as models of animal drug metabolism to study the transformation of the fluorinated drugs flurbiprofen and flutamide. These organisms are widely employed as models of mammalian metabolism, but their application to the transformation of fluorinated drugs has not yet been investigated. The study will employ fluorine-19 nuclear magnetic resonance as a primary technique to monitor biotransformation.

Grant Approved

�95,000.00

Research Hub

Green and Circular Economy

Research Theme

Waste and Resources Management

Start Date

01/10/2008

Initial Projected Completion Date

01/10/2011