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Project Code [2008-PhD-WRM-3]
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Project title
Fungi and fluorinated drugs the development of microbial models of mammalian metabolism
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
University College Dublin (UCD)
Lead Applicant
Cormac Murphy
Project Abstract
Drug discovery necessitates the use of animals for catabolic and toxicological studies. The European Union?s REACH initiative has as one of its priorities the development of novel methods to replace the dependence on animal testing. To this end it is proposed to investigate the potential of the fungus Cunninghamella elegans and the bacterium Streptomyces giseus as models of animal drug metabolism to study the transformation of the fluorinated drugs flurbiprofen and flutamide. These organisms are widely employed as models of mammalian metabolism, but their application to the transformation of fluorinated drugs has not yet been investigated. The study will employ fluorine-19 nuclear magnetic resonance as a primary technique to monitor biotransformation.
Grant Approved
�95,000.00
Research Hub
Green and Circular Economy
Research Theme
Waste and Resources Management
Initial Projected Completion Date
01/10/2011