Search the EPA Research Database
Project Search Result
Project Code [2006-PhD-ET-8]
This information is correct as of today and is updated from time to time by the EPA to reflect changes in the management of the project. Please check back regularly for updates.
Project title
Novel alcohol dehydrogenases for the synthesis of chiral alcohols
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
University College Dublin (UCD)
Lead Applicant
Francesca Paradisi
Project Abstract
Enzymes from extremophiles (organisms which live in extreme environments) have unusual characteristics of stability and tolerance to harsh working reaction conditions making them extremely appealing for bio-applications and industrial scale-ups. The aim of this project is to clone an alcohol dehydrogenase (ADH) from Halobacterium salinarum an archaebacterium which thrives in highly-salted water to investigate its properties. ADHs can reduce ketones to secondary chiral alcohols which together with their derivatives are in great demand from the pharmaceutical industry. This project targets the production of valuable molecules via bio-catalysis employing a robust biocatalyst (enzyme) with minimal impact on the environment (green chemistry).
Grant Approved
�90,000.00
Research Hub
Green and Circular Economy
Research Theme
Waste and Resources Management
Initial Projected Completion Date
05/01/2011