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Project Code [2006-PhD-ET-6]
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Project title
Photochemical Alternatives to Hazardous Radical Initiators for the Synthesis of Potent Anti-tumour Agents
Primary Funding Agency
Environmental Protection Agency
Co-Funding Organisation(s)
n/a
Lead Organisation
National University of Ireland Galway (NUIG)
Lead Applicant
Fawaz Aldabbagh
Project Abstract
Bioreductive anti-tumour agents require reductive activation to manifest their cytotoxicity which makes them selective towards hypoxic (anaerobic) environments of tumour cells. We have prepared novel benzimidazolequinones which are much more cytotoxic and selective than the clinically used drug Mitomycin C. The key synthetic step involves free radical cyclizations using tributyltin hydride and azo-initiators. Such radical initiators are widely used but are exceedingly toxic unstable hazardous and provide separation and disposal problems. The following project aims to prepare new highly potent molecules using photochemical cyclizations carried out in the absence of radical initiators with adaptation to solar chemical conditions.
Grant Approved
�90,000.00
Research Hub
Green and Circular Economy
Research Theme
Waste and Resources Management
Initial Projected Completion Date
05/07/2011