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Project Code [2006-PhD-ET-6]

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Project title

Photochemical Alternatives to Hazardous Radical Initiators for the Synthesis of Potent Anti-tumour Agents

Primary Funding Agency

Environmental Protection Agency

Co-Funding Organisation(s)

n/a

Lead Organisation

National University of Ireland Galway (NUIG)

Lead Applicant

Fawaz Aldabbagh

Project Abstract

Bioreductive anti-tumour agents require reductive activation to manifest their cytotoxicity which makes them selective towards hypoxic (anaerobic) environments of tumour cells. We have prepared novel benzimidazolequinones which are much more cytotoxic and selective than the clinically used drug Mitomycin C. The key synthetic step involves free radical cyclizations using tributyltin hydride and azo-initiators. Such radical initiators are widely used but are exceedingly toxic unstable hazardous and provide separation and disposal problems. The following project aims to prepare new highly potent molecules using photochemical cyclizations carried out in the absence of radical initiators with adaptation to solar chemical conditions.

Grant Approved

�90,000.00

Research Hub

Green and Circular Economy

Research Theme

Waste and Resources Management

Start Date

01/10/2006

Initial Projected Completion Date

05/07/2011