Search the EPA Research Database

Project Search Result

Project Code [2007-PhD-EH-1]

This information is correct as of today and is updated from time to time by the EPA to reflect changes in the management of the project. Please check back regularly for updates.

Project title

Role of engineered nanoparticles in protein fibrillation diseases

Primary Funding Agency

Environmental Protection Agency

Co-Funding Organisation(s)

n/a

Lead Organisation

University College Dublin (UCD)

Lead Applicant

Kenneth Dawson

Project Abstract

The health and safety aspects of nanoparticles released into the environment (either intentionally, such as in controlled release products for agriculture, or accidentally, as waste products, spillages, etc.) is at present entirely unknown. What is known, is that nanoparticles can reach all areas of the body, including the brain, and that their enormous surface area offers potential for considerable adsorption of proteins, with subsequent alterations in protein aggregation and function. Our preliminary results show that nanoparticles such as cerium oxide (used in fuels and released as emissions) can modulate the rate of protein fibrillation in vitro, highlighting a pressing need for further research.

Grant Approved

�95,000.00

Research Hub

Healthy Environment

Research Theme

Environment and Human Health

Start Date

20/08/2007

Initial Projected Completion Date

20/08/2010